Advanced Platelet-rich Fibrin versus Sticky Bone in Socket Preservation - Clinical and X-ray Assessment: Case Report

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Stavre Trajculeski
Daniela Veleska-Stevkovska
Marija Trajculeski


BACKGROUND: The preservation of post-extraction alveola, as part of guided bone regeneration, is recommended for the creation of a biological foundation for future implant-prosthetic or prosthetic production. Several graft materials are used, either independently or in a combination of each other. Advanced platelet-rich fibrin (A-PRF) as an autologous blood derivate in the recent years has been increasingly used because of its properties in angiogenesis, epithelialization, and hemostasis. Simple production, low cost, and non-use of anticoagulants are advantages for more mass use of it.

CASE PRESENTATION: Two clinical cases are described, one is using a combination of A-PRF with xenograft, and the second clinical case is using a solo A-PRF, for socket preservation.

CONCLUSION: The properties of A-PRF for preserving both bone volume and quality have been confirmed, highlighting its potential as a valuable therapeutic tool. Furthermore, the post-operative period following A-PRF treatment has been found to be free of significant discomfort and morbidity for patients, suggesting that this approach may represent a safe and effective means of promoting optimal clinical outcomes.


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Trajculeski S, Veleska-Stevkovska D, Trajculeski M. Advanced Platelet-rich Fibrin versus Sticky Bone in Socket Preservation - Clinical and X-ray Assessment: Case Report. SEE J Immunol [Internet]. 2023 Jun. 6 [cited 2023 Sep. 23];6(1):12-7. Available from:
Basic Immunology


Buchwald S, Kocher T, Biffar R, Harb A, Holtfreter B, Meisel P. Tooth loss and periodontitis by socio-economic status and inflammation in a longitudinal population-based study. J Clin Periodontol. 2013;40(3):203-11. PMid:23379538

Araújo MG, Silva CO, Misawa M, Sukekava F. Alveolar socket healing: What can we learn? Periodontol 2000. 2015;68(1):122-34. PMid:25867983

Araújo MG, Lindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 2005;32(2):212-8. PMid:15691354

Schropp L, Wenzel A, Kostopoulos L, Karring T. Bone healing and soft tissue contour changes following single-tooth extraction: A clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent. 2003;23(4):313-23. PMid:12956475

McAllister BS, Haghighat K. Bone augmentation techniques. J Periodontol. 2007;78(3):377-96. PMid:17335361

Hämmerle CH, Araújo MG, Simion M, Osteology Consensus Group 2011. Evidence-based knowledge on the biology and treatment of extraction sockets. Clin Oral Implants Res. 2012;23 Suppl 5:80-2. Erratum in: Clin Oral Implants Res. 2012;23(5):641. PMid:22211307

Jamjoom A, Cohen RE. Grafts for ridge preservation. J Funct Biomater. 2015;6(3):833-48. PMid:26262646

Miron RJ, Hedbom N, Saulacic Y, Zhang Y, Sculean A, Bosshardt DD, et al. Osteogenic potential of autogenous bone grafts harvested with four different surgical techniques. J Dent Res. 2011;90(12):1428-33. PMid:21940523

Choukroun J, Adda F, Schoeffler C, Vervelle A. An opportunity in implantology: The PRF. Implantodontie. 2001;42:55-62.

Marx RE. Platelet-rich plasma: Evidence to support its use. J Oral Maxillofac Surg. 2004;62(4):489-96. PMid:15085519

Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e45-50. PMid:16504850

Al-Hamed FS, Mahri M, Al-Waeli H, Torres J, Badran Z, Tamimi F. Regenerative effect of platelet concentrates in oral and craniofacial regeneration. Front Cardiovasc Med. 2019;6:126. PMid:31552270

Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier JB. Three-dimensional architecture and cell composition of a Choukroun’s platelet-rich fibrin clot and membrane. J Periodontol. 2010;81(4):546-55. PMid:20373539

Kawase T, Okuda K, Wolff LF, Yoshie H. Platelet-rich plasma- derived fibrin clot formation stimulates collagen synthesis in periodontal ligament and osteoblastic cells in vitro. J Periodontol. 2003;74(6):858-64. PMid:12886997

Del Corso M, Vervelle A, Simonpieri A, Jimbo R, Inchingolo F, Sammartino G, et al. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 1: Periodontal and dentoalveolar surgery. Curr Pharm Biotechnol. 2012;13(7):1207-30. PMid:21740371

Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part III: Leucocyte activation: A new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e51-5. tripleo.2005.07.010 PMid:16504851

Kobayashi E, Flückiger L, Fujioka-Kobayashi M, Sawada K, Sculean A, Schaller B, et al. Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 2016;20(9):2353-60. PMid:26809431

Yewale M, Bhat S, Kamath A, Tamrakar A, Patil V, Algal AS.

Advanced platelet-rich fibrin plus and osseous bone graft for socket preservation and ridge augmentation-a randomized control clinical trial. J Oral Biol Craniofac Res. 2021;11(2):225-33. PMid:33665072

Nevins ML, Camelo M, Schupbach P, Kim DM, Camelo JM, Nevins M. Human histologic evaluation of mineralized collagen bone substitute and recombinant platelet-derived growth factor-BB to create bone for implant placement in extraction socket defects at 4 and 6 months: A case series. Int J Periodontics Restorative Dent. 2009;29(2):129-39. PMid:19408475

Anwandter A, Bohmann S, Nally M, Castro AB, Quirynen M, Pinto N. Dimensional changes of the post extraction alveolar ridge, preserved with leukocyte-and platelet rich fibrin: A clinical pilot study. J Dent. 2016;52:23-9. https://doi.org10.1016/j.jdent.2016.06.005 PMid:27338946

Temmerman A, Vandessel J, Castro A, Jacobs R, Teughels W, Pinto N, et al. The use of leucocyte and platelet-rich fibrin in socket management and ridge preservation: A split-mouth, randomized, controlled clinical trial. J Clin Periodontol. 2016;43(11):990-9. PMid:27509214

Tatullo M, Marrelli M, Cassetta M, Pacifici A, Stefanelli LV, Scacco S, et al. Platelet rich fibrin (P.R.F.) in reconstructive surgery of atrophied maxillary bones: Clinical and histological evaluations. Int J Med Sci. 2012;9(10):872-80. PMid:23155361

Areewong K, Chantaramungkorn M, Khongkhunthian P. Platelet-rich fibrin to preserve alveolar bone sockets following tooth extraction: A randomized controlled trial. Clin Implant Dent Relat Res. 2019;21(6):1156-63. PMid:31647177

Uyanik LO, Bilginaylar K, Etikan İ. Effects of platelet-rich fibrin and piezosurgery on impacted mandibular third molar surgery outcomes. Head Face Med. 2015;11:25. PMid:26209242

Kumar N, Prasad K, Ramanujam K, Dexith J, Ranganath K, Chauhan A. Evaluation of treatment outcome after impacted mandibular third molar surgery with the use of autologous platelet-rich fibrin: A randomized controlled clinical study. J Oral Maxillofac Surg. 2015;73(6):1042-1049. PMid:25659357