Topical Formulation Based on Arnebia euchroma as a Novel Possible Efficient Treatment on Epidermolysis Bullosa Lesions: A Case Series of Fourteen Patients

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Amirsaleh Abdollahi
Rouzbeh Kadkhodaee
Armaghan Kazeminejad
Lotfollah Davoodi
Muhammadreza Oraee Karimi
Alireza Razavi
Sobhan Mohebbi Najmabad


BACKGROUND: Epidermolysis bullosa (EB) is a skin fragility disorder that results in the disruption of the dermo-epidermal junction and painful blisters on the skin and mucous membranes. Currently, there is almost no definite treatment for EB patients.

AIM: This study aims to assess the effect of topical formulation based on Arnebia euchroma (AE) on lesions induced by EB.

MATERIALS AND METHODS: All patients with EB diseases treated with Hochobeh ointment (AE+Beewax+Olive oil) in 2022 at our dermatological clinic were included in the study. EB diseases were diagnosed based on the following criteria: (1) clinical features (2) histopathological findings (3) Linear depositions of IgG, IgA, IgM 4. salt-split skin (SSS) or other immune serological tests compatible with the diagnosis of EB disease. Hochobeh ointment and lotion treatment were initiated. Clinical evaluations were repeated 3 and 7 days after the treatment began, and photographs were taken to document the changes in clinical severity. EB Disease Activity and Scarring Index (EBDASI) and EB Quality of Life (EB-QoL) questionnaires were used to assess the severity of EB and the quality of life, respectively. All statistical analyses were performed using statistical package for the social sciences version 16.

RESULTS: Overall, fourteen patients were included. Improvement in clinical features, including reduction of infection and inflammation and improvement of wound healing, was observed. EBDASI and EB-QoL scores decreased significantly after treatment (91.5 ± 45.7 vs. 68.9 ± 43, p = 0.001; 24.6 ± 6.7 vs. 18 ± 5.2, p = 0.001, respectively).

CONCLUSION: Hochobeh ointment may be effective in treating EB skin and mucosal lesions.


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Abdollahi A, Kadkhodaee R, Kazeminejad Armaghan, Davoodi L, Karimi MO, Razavi A, Najmabad SM. Topical Formulation Based on Arnebia euchroma as a Novel Possible Efficient Treatment on Epidermolysis Bullosa Lesions: A Case Series of Fourteen Patients. SEE J Immunol [Internet]. 2023 Jul. 20 [cited 2024 May 20];6(1):56-61. Available from:
Clinical Immunology


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